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美沙酮治疗的剂量模式:1988 - 2005年全国调查结果

Dosage patterns in methadone treatment: results from a national survey, 1988-2005.

作者信息

Pollack Harold A, D'Aunno Thomas

机构信息

Center for Health Administration Studies, University of Chicago, 969 East 60th St., Chicago, IL 60637, USA.

出版信息

Health Serv Res. 2008 Dec;43(6):2143-63. doi: 10.1111/j.1475-6773.2008.00870.x. Epub 2008 Jun 3.

Abstract

OBJECTIVE

To examine the extent to which U.S. methadone maintenance facilities meet established standards for minimum dosages, 1988-2005.

DATA SOURCE

Data were collected from a nationally representative sample of outpatient treatment facilities in 1988 (n=172), 1990 (n=140), 1995 (n=116), 2000 (n=150), and 2005 (n=146).

STUDY DESIGN

Random-effects multiple regression analysis was used to examine unit characteristics associated with below recommended doses.

DATA COLLECTION

Data regarding the proportion of patients who received maintenance dosages of <40, 60, and 80 mg/day were collected from unit directors and clinical supervisors.

PRINCIPAL FINDINGS

Forty-four percent of patients receive doses of at least 80 mg/day--the threshold identified as recommended practice in recent work. Thirty-four percent of patients receive doses below 60 mg/day, while 17 percent receive doses below 40 mg/day. Units that serve a high proportion of African American or Latino clients were more likely to report low-dose care. Units managed by individuals who strongly favor abstinence models (e.g., Narcotics Anonymous) were more likely to provide low-dose care.

CONCLUSIONS

One-third of methadone facilities provide doses below recommended levels. Managerial attitudes about abstinence and their relationship to low doses underscore the contested role of methadone in treatment of opiate disorders.

摘要

目的

研究1988 - 2005年美国美沙酮维持治疗机构达到既定最低剂量标准的程度。

数据来源

数据收集自1988年(n = 172)、1990年(n = 140)、1995年(n = 116)、2000年(n = 150)和2005年(n = 146)具有全国代表性的门诊治疗机构样本。

研究设计

采用随机效应多元回归分析来研究与低于推荐剂量相关的机构特征。

数据收集

从机构主任和临床主管处收集接受每日维持剂量<40毫克、60毫克和80毫克的患者比例的数据。

主要发现

44%的患者接受至少80毫克/天的剂量——这是近期研究中确定为推荐做法的阈值。34%的患者接受低于60毫克/天的剂量,而17%的患者接受低于40毫克/天的剂量。为非裔美国或拉丁裔客户比例高的机构更有可能报告低剂量治疗。由强烈支持禁欲模式(如匿名戒毒会)的个人管理的机构更有可能提供低剂量治疗。

结论

三分之一的美沙酮治疗机构提供低于推荐水平的剂量。对禁欲的管理态度及其与低剂量的关系凸显了美沙酮在阿片类药物障碍治疗中存在争议的作用。

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