Nanjundiah V, Malchow D
J Cell Sci. 1976 Oct;22(1):49-58. doi: 10.1242/jcs.22.1.49.
During aggregation the larger Dictyostelium species use cAMP as a chemoattractant and possibly also as a transmitter. In passage from cell to cell, cAMP levels are modulated by diffusion and by enzyme hydrolysis. It appears that the important cAMP-hydrolysing enzyme is a phosphodiesterase bound to the cell membrane, the main roles of which are (1) very fast hydrolysis of cAMP and (2) steepening of spatial cAMP gradients. An extracellular phosphodiesterase has no function, so far as can be conjectured from present data.
在聚集过程中，较大的盘基网柄菌属物种将环磷酸腺苷（cAMP）用作趋化剂，可能还用作递质。在细胞间传递时，cAMP水平通过扩散和酶水解进行调节。看来，重要的cAMP水解酶是一种与细胞膜结合的磷酸二酯酶，其主要作用是：（1）非常快速地水解cAMP；（2）使空间cAMP梯度变陡。就目前的数据推测，细胞外磷酸二酯酶没有功能。
