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细胞黏菌对趋化因子叶酸的失活作用及反应产物的鉴定

Inactivation of the chemoattractant folic acid by cellular slime molds and identification of the reaction product.

作者信息

Pan P, Wurster B

出版信息

J Bacteriol. 1978 Dec;136(3):955-9. doi: 10.1128/jb.136.3.955-959.1978.

DOI:10.1128/jb.136.3.955-959.1978
PMID:569146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218530/
Abstract

Enzymes inactivating the chemoattractants folic acid and pterin were detected in extracellular, intracellular, and particulate fractions obtained from Dictyostelium discoideum strains NC4 and AX-2 and Polysphondylium violaceum. The products of the inactivation reaction were analyzed by thin-layer chromatography and UV spectroscopy. Results obtained indicate that folic acid and pterin were deaminated to 2-deamino folic acid and lumazine, respectively.

摘要

在从盘基网柄菌NC4和AX - 2菌株以及紫多头绒泡菌中获得的细胞外、细胞内和颗粒组分中检测到了使趋化因子叶酸和蝶呤失活的酶。通过薄层色谱法和紫外光谱法分析了失活反应的产物。所得结果表明，叶酸和蝶呤分别被脱氨基生成2 - 脱氨基叶酸和核黄素。

相似文献

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Inactivation of the chemoattractant folic acid by cellular slime molds and identification of the reaction product.细胞黏菌对趋化因子叶酸的失活作用及反应产物的鉴定
J Bacteriol. 1978 Dec;136(3):955-9. doi: 10.1128/jb.136.3.955-959.1978.
2
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本文引用的文献

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A bacterial pterin deaminase.一种细菌蝶呤脱氨酶。
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A new approach to the problem of aggregation in the cellular slime molds.细胞黏菌中聚集问题的一种新方法。
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Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.细胞黏菌盘基网柄菌的黏变形体在无菌培养中的生长。
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The acrasin activity of adenosine-3',5'-cyclic phosphate.3',5'-环磷酸腺苷的聚集素活性。
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152-4. doi: 10.1073/pnas.58.3.1152.
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Folic acid as second chemotactic substance in the cellular slime moulds.叶酸作为细胞黏菌中的第二种趋化物质。
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6
Defective cyclic adenosine-3', 5'-phosphate-phosphodiesterase regulation in morphogenetic mutants of Dictyostelium discoideum.盘基网柄菌形态发生突变体中环状腺苷 - 3',5'-磷酸磷酸二酯酶调节缺陷
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7
Adenosine 3':5'-cyclic monophosphate concentrations and phosphodiesterase activities during axenic growth and differentiation of cells of the cellular slime mould Dictyostelium discoideum.盘基网柄菌细胞无菌生长和分化过程中的3':5'-环磷酸腺苷浓度及磷酸二酯酶活性
Biochem J. 1973 May;134(1):311-9. doi: 10.1042/bj1340311.
8
Synthesis of cyclic AMP and phosphodiesterase in various species of cellular slime molds and its bearing on chemotaxis and differentiation.不同种类细胞黏菌中环磷酸腺苷的合成与磷酸二酯酶及其与趋化性和分化的关系
Dev Biol. 1972 Dec;29(4):402-9. doi: 10.1016/0012-1606(72)90080-2.
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Membrane-bound cyclic AMP phosphodiesterase in chemotactically responding cells of Dictyostelium discoideum.盘基网柄菌趋化反应细胞中的膜结合环磷酸腺苷磷酸二酯酶
Eur J Biochem. 1972 Jun 23;28(1):136-42. doi: 10.1111/j.1432-1033.1972.tb01894.x.
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Cyclic AMP phosphodiesterase and its inhibitor in slime mould development.环磷酸腺苷磷酸二酯酶及其抑制剂在黏菌发育中的作用
Nat New Biol. 1972 Jan 19;235(55):90-2. doi: 10.1038/newbio235090a0.