McCabe Martin G, Hook C Elizabeth, Burke G A Amos
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Pediatr Blood Cancer. 2008 Oct;51(4):557-9. doi: 10.1002/pbc.21637.
We report the spontaneous regression of an Epstein-Barr virus-associated monoclonal lymphoid proliferation in an immunocompetent child. A 2-year-old male with acute otitis media presented with a right-sided facial palsy secondary to acute mastoiditis. During mastoid decompression a polypoid mass, a histologically diffuse large B cell lymphoma, was found. Staging revealed localized disease. At surgical re-exploration 5 weeks later the disease had resolved. Retrospective serological testing was consistent with an acute Epstein-Barr viral infection and in situ hybridization of the tumour tissue was positive for Epstein-Barr RNA.
我们报告了一例免疫功能正常儿童中与爱泼斯坦-巴尔病毒相关的单克隆淋巴细胞增殖的自发消退。一名患有急性中耳炎的2岁男性因急性乳突炎出现右侧面瘫。在乳突减压过程中发现了一个息肉样肿块，组织学检查为弥漫性大B细胞淋巴瘤。分期显示为局限性疾病。5周后再次手术探查时，疾病已消退。回顾性血清学检测结果与急性爱泼斯坦-巴尔病毒感染一致，肿瘤组织的原位杂交检测显示爱泼斯坦-巴尔病毒RNA呈阳性。
