胃弥漫性大B细胞淋巴瘤的自发缓解及长达10年的缓解持续期

Spontaneous Remission of Diffuse Large B Cell Lymphoma in the Stomach and the Continuation of Remission for 10 Years.

作者信息

Sugiyama Toshiro, Arita Kotaro, Shinno Eiji, Nakajima Takahiko

机构信息

Department of Gastroenterology and Hematology, University of Toyama, Toyama, Japan.

Department of Gastroenterology, Shinseikai Toyama Hospital, Toyama, Japan.

出版信息

Case Rep Gastroenterol. 2018 Nov 28;12(3):699-703. doi: 10.1159/000494750. eCollection 2018 Sep-Dec.

DOI:10.1159/000494750

PMID:30631255

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6323366/

Abstract

According to the literature, spontaneous remission of aggressive lymphomas is extremely rare; gastric non-Hodgkin lymphomas, such as mucosa-associated lymphoid tissue lymphomas, often regress due to treatment or no progression, even in a watch-and-wait strategy. Although spontaneous remission of diffuse large B cell lymphomas in the stomach was very rarely reported, the follow-up periods of the cases of spontaneous remission are within 2 years and most cases are likely to relapse after the first remission. Here, we report that a diffuse large B cell lymphoma in the stomach showed spontaneous remission within 2 months after the initial diagnosis and the remission is still continuing for 10 years without any specific treatments against this aggressive lymphoma.

摘要

根据文献记载，侵袭性淋巴瘤的自发缓解极为罕见；胃非霍奇金淋巴瘤，如黏膜相关淋巴组织淋巴瘤，即便采用观察等待策略，通常也会因治疗而病情缓解或无进展。虽然胃弥漫性大B细胞淋巴瘤自发缓解的报道极为罕见，但自发缓解病例的随访期均在2年内，且大多数病例在首次缓解后可能复发。在此，我们报告一例胃弥漫性大B细胞淋巴瘤在初诊后2个月内出现自发缓解，且在未针对这种侵袭性淋巴瘤进行任何特殊治疗的情况下，缓解状态持续了10年。