Ito Yasushi, Oguni Hirokazu, Funatsuka Makoto, Osawa Makiko
Department of Pediatrics, School of Medicine, Tokyo Women's Medical University, Tokyo.
No To Hattatsu. 2008 May;40(3):244-8.
The clinical observations of seven patients with epileptic seizures and colpocephaly were summarized. The ages at the time of onset of the seizures were usually under 1 year, and the frequency of seizures in the late-onset cases was lower than that in the early-onset cases. The seizures were characterized by vomiting, eye deviation, versive seizures, and focal motor seizures. Interictal electroencephalograms showed either unilateral or synchronous bilateral spikes (and wave) or slowing of the basic activity in the occipital area. The basic activity slowed down in all of the cases. Epileptic seizures accompanied with colpocephaly may derive from epileptic foci in the occipital and posterior temporal region, which is structurally abnormal. Ongoing convulsions ceased after the intravenous administration of diazepam. In addition, the oral antiepileptics clobazam and clorazepate proved to be effective for the treatment of refractory cases.
总结了7例患有癫痫发作和脑室后部扩大的患者的临床观察结果。癫痫发作开始时的年龄通常在1岁以下，晚发性病例的癫痫发作频率低于早发性病例。癫痫发作的特征为呕吐、眼球偏斜、旋转性癫痫发作和局灶性运动性癫痫发作。发作间期脑电图显示单侧或同步双侧尖波（和慢波）或枕区基础活动减慢。所有病例的基础活动均减慢。伴有脑室后部扩大的癫痫发作可能源于枕叶和颞叶后部结构异常的癫痫病灶。静脉注射地西泮后持续的惊厥停止。此外，口服抗癫痫药氯巴占和氯氮卓对难治性病例的治疗有效。
