Ferrucci R, Mameli F, Guidi I, Mrakic-Sposta S, Vergari M, Marceglia S, Cogiamanian F, Barbieri S, Scarpini E, Priori A
Department of Neurological Sciences, University of Milan, Ospedale Maggiore Policlinico, Padiglione Ponti, V F Sforza 35, Milan 20122, Italy.
Neurology. 2008 Aug 12;71(7):493-8. doi: 10.1212/01.wnl.0000317060.43722.a3. Epub 2008 Jun 4.
To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD).
In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation).
After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 +/- 0.9, poststimulation: 17.9 +/- 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 +/- 0.6 vs 13.2 +/- 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 +/- 0.7 vs 16.0 +/- 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged.
Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD.
评估经颅直流电刺激（tDCS）对阿尔茨海默病（AD）患者颞顶叶区域的认知影响。
对10例可能患有AD的患者，分三个阶段在颞顶叶区域给予阳极tDCS（AtDCS）、阴极tDCS（CtDCS）和假tDCS（StDCS）。在每个阶段，于基线（刺激前）和tDCS结束后30分钟（刺激后）测试识别记忆和视觉注意力。
AtDCS后，单词识别记忆任务的准确率提高（刺激前：15.5±0.9，刺激后：17.9±0.8，p = 0.0068）；而CtDCS后准确率降低（15.8±0.6对13.2±0.9，p = 0.011），StDCS后则保持不变（16.3±0.7对16.0±1.0，p = 0.75）。tDCS对视觉注意力反应时间无影响。
经颅直流电刺激（tDCS）作用于颞顶叶区域可特异性影响阿尔茨海默病（AD）患者的识别记忆表现。由于tDCS简单、安全且成本低廉，我们的发现促使开展使用重复tDCS并结合其他治疗干预措施治疗AD患者的研究。
