Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-Ro, Yeongdeungpo-Gu, Seoul, 06591, Republic of Korea.
Sci Rep. 2024 Aug 13;14(1):18818. doi: 10.1038/s41598-024-67664-9.
Despite the growing interest in precision medicine-based therapies for Alzheimer's disease (AD), little research has been conducted on how individual AD risk factors influence changes in cognitive function following transcranial direct current stimulation (tDCS). This study evaluates the cognitive effects of sequential tDCS on 63 mild cognitive impairment (MCI) patients, considering AD risk factors such as amyloid-beta deposition, APOE ε4, BDNF polymorphism, and sex. Using both frequentist and Bayesian methods, we assessed the interaction of tDCS with these risk factors on cognitive performance. Notably, we found that amyloid-beta deposition significantly interacted with tDCS in improving executive function, specifically Stroop Word-Color scores, with strong Bayesian support for this finding. Memory enhancements were differentially influenced by BDNF Met carrier status. However, sex and APOE ε4 status did not show significant effects. Our results highlight the importance of individual AD risk factors in modulating cognitive outcomes from tDCS, suggesting that precision medicine may offer more effective tDCS treatments tailored to individual risk profiles in early AD stages.
尽管人们对基于精准医学的阿尔茨海默病（AD）疗法越来越感兴趣，但关于个体 AD 风险因素如何影响经颅直流电刺激（tDCS）后认知功能的变化，研究甚少。本研究评估了顺序 tDCS 对 63 名轻度认知障碍（MCI）患者的认知影响，考虑了 AD 风险因素，如淀粉样蛋白-β沉积、APOE ε4、BDNF 多态性和性别。本研究使用了频率论和贝叶斯方法，评估了 tDCS 与这些风险因素在认知表现上的相互作用。值得注意的是，我们发现淀粉样蛋白-β沉积与 tDCS 在改善执行功能方面显著相互作用，特别是在 Stroop 词色分数上，这一发现得到了强有力的贝叶斯支持。BDNF Met 携带者状态对记忆增强有不同的影响。然而，性别和 APOE ε4 状态没有显示出显著的影响。我们的结果强调了个体 AD 风险因素在调节 tDCS 认知结果中的重要性，表明精准医学可能为早期 AD 阶段基于个体风险概况的更有效 tDCS 治疗提供了可能性。
