Haney Elizabeth M, Bliziotes M Michael
Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
Curr Opin Rheumatol. 2008 Jul;20(4):423-8. doi: 10.1097/BOR.0b013e3283025eb0.
Osteoporosis in men is increasingly recognized as an important health problem. New research contributes to our knowledge of gender differences in osteoporosis risk, diagnosis and management. We undertook this review to summarize recent developments in the field of male osteoporosis.
The paper reviews recently published studies that reveal new insights into male osteoporosis. It addresses epidemiology, risk factors, use of clinical risk assessment tools, diagnosis and treatment. New data continue to suggest that men have higher mortality rates than women after hip fracture, and that men may experience fractures at higher bone mineral density values than women. Treatments for osteoporosis have been studied mostly in women, but trials including both men and women are now being conducted. Likewise, there are several newer cohorts with bone and fracture outcomes that include men and women. The Osteoporotic Fractures in Men (MrOS) study is the first United States-based cohort to include only men; this study is contributing importantly to our understanding of epidemiology and risk factors for osteoporosis in men.
Men and their physicians should be aware of the risk for osteoporosis and the gender differences that exist within this disease. Further research is needed to continue to understand differences in pathophysiology, epidemiology and risk factors, and to promote appropriate therapies among men.
男性骨质疏松症日益被视为一个重要的健康问题。新的研究增进了我们对骨质疏松症在风险、诊断和管理方面性别差异的认识。我们进行本综述以总结男性骨质疏松领域的最新进展。
本文回顾了最近发表的揭示男性骨质疏松症新见解的研究。涉及流行病学、风险因素、临床风险评估工具的使用、诊断和治疗。新数据持续表明，男性髋部骨折后的死亡率高于女性，且男性可能在比女性更高的骨密度值时发生骨折。骨质疏松症的治疗大多在女性中进行研究，但现在正在开展包括男性和女性的试验。同样，有几个更新的包含骨和骨折结局的队列研究纳入了男性和女性。男性骨质疏松性骨折（MrOS）研究是美国首个仅纳入男性的队列研究；该研究对我们理解男性骨质疏松症的流行病学和风险因素做出了重要贡献。
男性及其医生应意识到骨质疏松症的风险以及该疾病中存在的性别差异。需要进一步研究以持续了解病理生理学、流行病学和风险因素方面的差异，并在男性中推广适当的治疗方法。
