Sørensen T I, Lund-Sørensen I L
Medicinsk Afsnit 261, Hvidovre Hospital.
Nord Med. 1991;106(6-7):182-3, 204.
Parallel with biochemical and physiological research into functional disturbances possibly leading to obesity, the focus of genetic and epidemiological research has been the aetiology of obesity. There is no longer any doubt that there are both genetic and environmental causes. Polygenic factors, and possibly recessive monogenic inheritance would seem to be involved. Aggregation of environmental factors at the family level may be decisive so long as the family members still live together, but other environmental factors are equally important. It will be the task of future research to identify the genes and environmental factors involved, thus providing a rational basis for effective prophylaxis.
在对可能导致肥胖的功能障碍进行生化和生理研究的同时，遗传和流行病学研究的重点一直是肥胖的病因。毫无疑问，肥胖存在遗传和环境两方面的原因。多基因因素以及可能的隐性单基因遗传似乎都与之相关。只要家庭成员仍生活在一起，家庭层面环境因素的聚集可能具有决定性作用，但其他环境因素同样重要。确定其中涉及的基因和环境因素将是未来研究的任务，从而为有效预防提供合理依据。
