Schendel S A, Pearl R M, De Armond S J
Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Calif.
Plast Reconstr Surg. 1991 Aug;88(2):197-200. doi: 10.1097/00006534-199108000-00003.
Muscle biopsy specimens taken from the upper lip and perialar area during the time of secondary lip revision and studied by histochemical techniques demonstrate persistent connective-tissue and muscle abnormalities even at a distance from the cleft margins. Some of these changes are consistent with surgically induced denervation-reinnervation of muscle groups in the surgical field. Increased amounts of connective tissue also were found, most likely secondary to the original deformity and the subsequent surgical procedures. Both these changes may be important factors in subsequent abnormal growth and development of the underlying midfacial structures. This study also demonstrated the resolution of previously noted mitochondrial abnormalities found in the primary cleft lip patient.
在二期唇修复术时从患者上唇和鼻翼周围区域采集的肌肉活检标本，经组织化学技术研究显示，即使在距腭裂边缘一定距离处，仍存在持续的结缔组织和肌肉异常。其中一些变化与手术区域肌肉群的手术诱导去神经再支配相一致。还发现结缔组织数量增加，这很可能继发于最初的畸形和后续的手术操作。这两种变化都可能是导致潜在中面部结构随后异常生长发育的重要因素。本研究还证实了原发性唇裂患者先前发现的线粒体异常已得到解决。
