An efficient solid-phase synthesis of 3-substituted and 3,3-disubstituted 1,2-dialkylpyrazolidine-3,5-diones.

An efficient and regioselective procedure for the synthesis of di-, tri- and fully-substituted pyrazolidine-3,5-diones on a solid-phase format is described. Microwave irradiation provided significant rate enhancement in this protocol. To demonstrate the versatility of this chemistry, a representative set of 25 compounds was prepared.