Terzin A L, Masic M G
J Hyg (Lond). 1976 Oct;77(2):155-60. doi: 10.1017/s0022172400024578.
Sera of 1255 individuals from Novi Sad, varying in age from less than 1 month to 69 years, have been tested for neutralization antibodies to Herpes implex virus type 1. The eight newborns tested and 97% of the 507 adults were positive, with titres ranging from 1/4 to 1/256. The titres in newborns were significantly lower than the titres in adults. After birth the maternal antibodies declined rapidly and 94% of infants at the age of greater than 6 months and less than 2 years were negative. After the first year infants in Novi Sad start to acquire herpes-neutralizing antibodies actively, reaching a 50% incidence of positives between the 2nd and 3rd year of age. Age-specific incidence rates of herpes positives found in Novi Sad have been compared with those reported from Edinburgh, Freiburg i. Br. and Louisiana. Possible influences of several circumstances upon the incidence rate of positives detected by the neutralization test are discussed.
对来自诺维萨德的1255名年龄从不到1个月至69岁不等的个体的血清进行了1型单纯疱疹病毒中和抗体检测。检测的8名新生儿以及507名成年人中的97%呈阳性，滴度范围为1/4至1/256。新生儿的滴度显著低于成年人。出生后，母体抗体迅速下降，6个月以上且不到2岁的婴儿中有94%呈阴性。在诺维萨德，婴儿在1岁后开始积极获得疱疹中和抗体，在2至3岁之间阳性发生率达到50%。已将诺维萨德发现的疱疹阳性的年龄特异性发病率与爱丁堡、弗赖堡（布雷斯劳）和路易斯安那报告的发病率进行了比较。讨论了几种情况对中和试验检测到的阳性发病率的可能影响。
