Sahoo Maheswar, Sekhri Tarun, Tripathi Madhabi, Rautela N, Solanki Y
Department of Cytology, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Diagn Cytopathol. 2008 Jul;36(7):519-22. doi: 10.1002/dc.20833.
The thyroid follicles represent a biological continuum. Each follicle is closely related to the follicle that is next to it. The important feature of a follicular carcinoma is a microfollicular pattern. We report a case of follicular carcinoma in a 48-year-old female that demonstrates microfollicles which are larger in size and contain more number of follicular cells in cytologic smears (20-29 cells) in contrary to the literature definition of microfollicles containing approximately 6-12 cells. We also demonstrate absence of basement membranes in these microfollicles in histologic sections by Silver Methanamine Stain, which may be an indicator to search for vascular and capsular invasion. This case report also describes postoperative positron emission tomography scan findings.
甲状腺滤泡代表一个生物学连续体。每个滤泡与其相邻的滤泡密切相关。滤泡癌的重要特征是微滤泡模式。我们报告一例48岁女性滤泡癌病例，该病例在细胞学涂片显示微滤泡更大，且含有更多滤泡细胞（20 - 29个细胞），这与文献中微滤泡含约6 - 12个细胞的定义相反。我们还通过嗜银染色在组织学切片中证实这些微滤泡缺乏基底膜，这可能是寻找血管和包膜侵犯的一个指标。本病例报告还描述了术后正电子发射断层扫描的结果。
