Paustenbach D J, Rinehart W E, Sheehan P J
ChemRisk, McLaren/Hart Environmental Engineering, Alameda, California 94501.
Regul Toxicol Pharmacol. 1991 Apr;13(2):195-222. doi: 10.1016/0273-2300(91)90022-n.
Between 1905 and 1971, over 2 million tons of residue from chromite ore processing was generated in Hudson County, New Jersey, of which substantial amounts were used as fill and tank diking. A panel of medical, toxicology, and risk assessment experts was convened in early 1990 to evaluate the potential health hazards posed by the resulting chromium contaminated soil. The Panel concluded that soils containing concentrations of 75 ppm hexavalent chromium [Cr(VI)] and 1000 ppm total chromium compounds (about 95% was trivalent chromium [Cr(III)]) did not pose a significant health hazard to nearby residents and workers. They also determined that exposure to chromium from Hudson County sites posed a negligible cancer hazard to residents. Using risk assessment methods, the Panel estimated that the plausible incremental cancer risk to individuals at residential sites would be substantially less than 1 in 1,000,000. The average measured levels of airborne Cr(VI) at typical industrial sites were more than 1000-fold lower than the current OSHA Permissible Exposure Limit (PEL). The maximum plausible increased cancer risk for an average worker at a dusty industrial site was estimated to be less than 1 in 100,000. The Panel also concluded that chromium-containing crystals, which have occasionally been found in Hudson County buildings, do not pose a significant hazard. However, they suggested that were the concentration to exceed 5000 ppm Cr(VI) in the crystals, site-specific health risk assessments would be conducted and remediation considered. The Panel evaluated the dermal hazard posed by chromium-contaminated soil and acknowledged that there is a small group of persons (approximately 0.1% of the United States population) who currently have a dermal sensitization to Cr(VI) primarily through occupational exposure. Based on published studies of human volunteers, the Panel concluded that a small percentage (less than 5%) of persons already sensitized may respond to Cr(VI) in solution at concentrations above 35 ppm. They decided that a much higher concentration in soil, perhaps 350 ppm Cr(VI), would be necessary to elicit dermatitis because only a fraction of the chromium in soil is soluble. The Panel concluded that it was highly unlikely (if not impossible) for a person to become dermally sensitized to Cr(VI) or Cr(III) at the soil concentrations found in most areas in Hudson County.(ABSTRACT TRUNCATED AT 400 WORDS)
1905年至1971年间,新泽西州哈德逊县产生了超过200万吨铬铁矿加工残渣,其中大量被用作填充物和罐体围堰。1990年初召集了一个由医学、毒理学和风险评估专家组成的小组,以评估由此产生的铬污染土壤所带来的潜在健康危害。该小组得出结论,六价铬[Cr(VI)]浓度为75 ppm且总铬化合物浓度为1000 ppm(约95%为三价铬[Cr(III)])的土壤不会对附近居民和工人构成重大健康危害。他们还确定,接触哈德逊县场地的铬对居民造成的癌症风险可忽略不计。通过风险评估方法,该小组估计,居住场所个人可能增加的合理癌症风险将大大低于百万分之一。典型工业场地空气中Cr(VI)的平均测量水平比职业安全与健康管理局(OSHA)当前的允许接触限值(PEL)低1000倍以上。在多尘工业场地,普通工人可能增加的最大合理癌症风险估计低于十万分之一。该小组还得出结论,在哈德逊县建筑物中偶尔发现的含铬晶体不会构成重大危害。然而,他们建议,如果晶体中Cr(VI)的浓度超过5000 ppm,将进行特定场地的健康风险评估并考虑进行修复。该小组评估了铬污染土壤造成的皮肤危害,并承认目前有一小部分人(约占美国人口的0.1%)主要通过职业接触对Cr(VI)有皮肤过敏反应。根据对人类志愿者的已发表研究,该小组得出结论,一小部分(不到5%)已经致敏的人可能会对浓度高于35 ppm的溶液中的Cr(VI)产生反应。他们认为,土壤中需要更高的浓度,也许是350 ppm Cr(VI)才会引发皮炎,因为土壤中的铬只有一小部分是可溶的。该小组得出结论,在哈德逊县大多数地区发现的土壤浓度下,一个人对Cr(VI)或Cr(III)产生皮肤过敏的可能性极小(如果不是不可能的话)。(摘要截断于400字)