Mikocka-Walus A A, Turnbull D A, Andrews J M, Moulding N T, Holtmann G J
School of Population Health and Clinical Practice, University of Adelaide, Adelaide, SA, Australia.
Aliment Pharmacol Ther. 2008 Aug 15;28(4):475-83. doi: 10.1111/j.1365-2036.2008.03754.x. Epub 2008 Jun 3.
Symptoms of functional gastrointestinal disorders (FGIDs) are common in patients with inflammatory bowel disease (IBD). Psychological comorbidities of anxiety and depression are also highly prevalent in IBD.
To quantify the burden of FGIDs in a hospital-based cohort of patients with IBD and to determine whether there is any inter-relationship between the presence and number of FGIDs and patients' quality of life or psychological status.
A cross-sectional survey of 61 out-patients was performed. Data on psychological status, quality of life, disease activity and functional symptoms according to Rome III criteria were collected.
Overall, 49 (80%) participants met Rome III criteria for a functional bowel disorder and 52% of participants met criteria for more than one FGID. Participants with no FGID had significantly better physical quality of life than those with more than two FGIDs (P = 0.025). However, there was no relationship among the number of FGIDs, mental quality of life, anxiety or depression.
Functional gastrointestinal disorders are highly prevalent in out-patients with IBD. Somewhat unexpectedly, the presence of anxiety and/or depression did not appear to correlate with either the presence or the number of FGIDs.
功能性胃肠疾病（FGIDs）的症状在炎症性肠病（IBD）患者中很常见。焦虑和抑郁等心理合并症在IBD患者中也非常普遍。
量化以医院为基础的IBD患者队列中FGIDs的负担，并确定FGIDs的存在及数量与患者生活质量或心理状态之间是否存在任何相互关系。
对61名门诊患者进行了横断面调查。收集了根据罗马III标准得出的心理状态、生活质量、疾病活动及功能症状的数据。
总体而言，49名（80%）参与者符合功能性肠病的罗马III标准，52%的参与者符合不止一种FGID的标准。无FGID的参与者的身体生活质量明显优于有两种以上FGID的参与者（P = 0.025）。然而，FGIDs的数量与心理生活质量、焦虑或抑郁之间没有关系。
功能性胃肠疾病在IBD门诊患者中非常普遍。有点出乎意料的是，焦虑和/或抑郁的存在似乎与FGIDs的存在或数量均无关联。
