Weil Dominique
CNRS FRE2937, Institut André Lwoff, 7 rue Guy Moquet, 94801 Villejuif cedex.
J Soc Biol. 2007;201(4):349-58. doi: 10.1051/jbio:2007905. Epub 2008 Mar 5.
What does mRNA become at the issue of translation in eukaryotic cells? It can be directly degraded or stored for further use. In some cases, the underlying molecular mechanisms have been studied in detail by biochemical approaches, as examplified by the most recently discovered regulation pathway, RNA interference. However, the cellular context of these regulations has often been ignored, as if these reactions took place diffusely throughout the cytoplasm. Two new structures involved therein have now been described: GW bodies (or P-bodies) and stress granules. The first studies suggested that they were specifically devoted to mRNA degradation and mRNA storage, respectively. This framework is changing rapidly with obvious functional overlapping between both structures.
在真核细胞的翻译过程中，信使核糖核酸（mRNA）会变成什么？它可以被直接降解或储存起来以供进一步使用。在某些情况下，通过生化方法已经对潜在的分子机制进行了详细研究，最近发现的RNA干扰调控途径就是一个例子。然而，这些调控的细胞环境常常被忽视，就好像这些反应在整个细胞质中分散发生一样。现在已经描述了其中涉及的两种新结构：GW小体（或P小体）和应激颗粒。最初的研究表明，它们分别专门负责mRNA降解和mRNA储存。随着这两种结构之间明显的功能重叠，这个框架正在迅速改变。
