Brundin Lena, Björkqvist Maria, Träskman-Bendz Lil, Petersén Asa
Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden.
J Affect Disord. 2009 Feb;113(1-2):179-82. doi: 10.1016/j.jad.2008.04.011. Epub 2008 Jun 3.
The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms.
Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays.
Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score.
The number of patients who participated was relatively small.
Our results support the hypothesis that orexin is involved in psychiatric symptomatology.
食欲素（下丘脑泌素）以及可卡因和苯丙胺调节转录肽（CART）是参与睡眠和食欲调节的下丘脑肽。我们之前已经表明，脑脊液（CSF）中食欲素-A和CART的水平与特定的精神症状有关。
10名患者在自杀未遂时以及6个月和12个月后接受了腰椎穿刺和精神评估。我们使用放射免疫分析法测量脑脊液中的食欲素和CART。
第一次和第二次随访时的脑脊液食欲素平均水平显著高于自杀未遂时。相比之下，脑脊液CART的平均水平随时间没有差异。随访时，SUAS总分以及CPRS第66项（整体疾病）评分显著降低。在一年时，脑脊液食欲素的变化与SUAS总分的变化之间存在显著负相关。
参与的患者数量相对较少。
我们的结果支持食欲素参与精神症状学的假说。
