Pridgeon Julia W, Zhao Liming, Becnel James J, Strickman Daniel A, Clark Gary G, Linthicum Kenneth J
Center for Medical, Agricultural, and Veterinary Entomology, USDA-ARS, 1600 SW 23rd Drive, Gainesville, FL 32608, USA.
J Med Entomol. 2008 May;45(3):414-20. doi: 10.1603/0022-2585(2008)45[414:taadrk]2.0.co;2.
Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti (AaeIAP1) was targeted for the development of molecular pesticides. Herein, for the first time, we report that topically applied AaeIAP1 double-stranded RNA products are able to kill female adults of Ae. aegypti. Our results indicate that critical pathways or genes could be targeted to develop molecular pesticides for the control of medically important diseases vectors.
埃及伊蚊（双翅目：蚊科）是登革热和黄热病的主要传播媒介。使用杀虫剂是控制这种具有重要医学意义的害虫的主要方法之一。然而，近年来很少有新的杀虫剂被开发用于控制蚊子。作为我们开发控制蚊子的新杀虫剂工作的一部分，埃及伊蚊凋亡抑制蛋白1基因（AaeIAP1）被作为开发分子农药的目标。在此，我们首次报告局部应用AaeIAP1双链RNA产品能够杀死埃及伊蚊的雌性成虫。我们的结果表明，可以针对关键途径或基因来开发用于控制具有重要医学意义的疾病传播媒介的分子农药。
