[Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis].

OBJECTIVE

To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).

METHOD

Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.

RESULT

A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.

CONCLUSION

5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.