奎宁和氯喹对血红素单体-二聚体平衡有不同的干扰作用。
Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium.
作者信息
Casabianca Leah B, An David, Natarajan Jayakumar K, Alumasa John N, Roepe Paul D, Wolf Christian, de Dios Angel C
机构信息
Department of Chemistry, Georgetown University, 37th and O Streets, NW, Washington, DC 20057, USA.
出版信息
Inorg Chem. 2008 Jul 7;47(13):6077-81. doi: 10.1021/ic800440d. Epub 2008 Jun 6.
Abstract
Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled mu-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the mu-oxo dimer whereas quinine promotes the monomer.
摘要
利用核磁共振（NMR）对磁化率的测量来研究高铁原卟啉（IX）的两种形式（高自旋单体与反铁磁耦合的μ-氧代二聚体）之间的平衡随pH值的变化。加入氯喹或奎宁会显著改变这种平衡对pH值的依赖性。氯喹促进μ-氧代二聚体的形成，而奎宁促进单体的形成。
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