Marulanda German A, Mont Michael A, Lucci Anthony, Letson G Douglas, Khakpour Nazanin
Department of Orthopedics & Sports Medicine, University of South Florida, 3500 E. Fletcher Avenue, Suite 511, MDC106. Tampa, FL 33613, USA.
Expert Rev Anticancer Ther. 2008 Jun;8(6):949-56. doi: 10.1586/14737140.8.6.949.
Breast cancer is the most common malignancy and the second leading cause of death in women. The metastatic involvement of bone denotes disease progression and decreased survival. Controversy exists regarding the exact pathophysiologic mechanism of metastasis and the different pathways that determine an osteoblastic versus osteoclastic bone compromise. Several breakthrough advances in imaging techniques aid in the detection, staging and follow-up of bone metastases. Although usually responsive to hormonal therapy and pharmacologic interventions, skeletal metastases often require some type of surgical intervention. Orthopedic surgeons should establish an active role in the multidisciplinary treatment of patients with breast cancer.
乳腺癌是女性中最常见的恶性肿瘤，也是第二大致死原因。骨转移意味着疾病进展和生存率降低。关于转移的确切病理生理机制以及决定成骨细胞与破骨细胞性骨破坏的不同途径存在争议。成像技术的几项突破性进展有助于骨转移的检测、分期和随访。尽管骨转移通常对激素治疗和药物干预有反应，但往往需要某种类型的手术干预。骨科医生应在乳腺癌患者的多学科治疗中发挥积极作用。
