Pratt Suzanne M, Christian John A, Paige Jackson L, Hawkins Jan F, Sojka Janice E
Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue Unniversity, West Lafayette, IN 47905, USA.
Vet Clin Pathol. 2008 Jun;37(2):253-5. doi: 10.1111/j.1939-165X.2008.00022.x.
A 16-year-old castrated male Arabian horse was presented to the Purdue University Veterinary Teaching Hospital with a 4-hour history of colic. Initial examinations provided strong evidence for small intestinal obstruction. Abdominal surgery revealed a strangulating lipoma, and 25 feet of small intestine were resected. Postoperatively, the horse developed obstructive ileus due to adhesion formation, which required a second laparotomy. During and after surgery, the abdomen was lavaged with sodium carboxymethylcellulose (CMC). One week after the second surgery, evaluation of peritoneal fluid revealed an inflammatory exudate, with many macrophages containing amorphous to granular, pink to magenta phagocytosed material. Extracellular aggregates of the material were also observed. The material was consistent with CMC. To our knowledge, this report is the first to demonstrate the phagocytosis of CMC by peritoneal fluid macrophages.
一匹16岁去势的雄性阿拉伯马因腹痛4小时被送至普渡大学兽医学院教学医院。初步检查有强有力的证据表明存在小肠梗阻。腹部手术发现一个绞窄性脂肪瘤，切除了25英尺的小肠。术后，这匹马因粘连形成出现麻痹性肠梗阻，需要进行第二次剖腹手术。手术期间及术后，用羧甲基纤维素钠（CMC）对腹腔进行灌洗。第二次手术后一周，对腹腔积液的评估显示有炎性渗出物，许多巨噬细胞含有无定形至颗粒状、粉红色至品红色的吞噬物质。还观察到该物质的细胞外聚集体。该物质与CMC一致。据我们所知，本报告首次证明腹腔积液巨噬细胞对CMC的吞噬作用。
