Kohn Yoav, Freedman Nanette, Lester Hava, Krausz Yodphat, Chisin Roland, Lerer Bernard, Bonne Omer
Department of Psychiatry and Medical Biophysics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Int J Neuropsychopharmacol. 2008 Sep;11(6):837-43. doi: 10.1017/S1461145708008936. Epub 2008 Jun 6.
Although patients suffering from major depression respond to antidepressant treatment within several weeks, full reinstatement of premorbid capabilities requires much longer. Nevertheless, most research in major depression seeking the pathophysiological correlates of remission has focused upon the acute post-treatment period. Brain imaging research offers no exception. We have recently shown that cerebral perfusion in depressed patients responding to 6-wk antidepressant medication increases in parieto/cerebellar regions and becomes similar to that of healthy control subjects. We now present technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (99mTc-HMPAO SPECT) data collected from 11 of these patients 2 years in remission. Images were analysed using Statistical Parametric Mapping. After 2 years, perfusion normalization found immediately after treatment was maintained, with further increases in frontal and decreases in parieto/cerebellar regions. These findings suggest that perfusion increases in parieto/cerebellar regions may be involved in acute response to treatment whereas increases in frontal regions may be related to its consolidation.
尽管患有重度抑郁症的患者在几周内对抗抑郁治疗有反应，但病前能力的完全恢复需要更长时间。然而，大多数关于重度抑郁症缓解的病理生理相关性的研究都集中在治疗后的急性期。脑成像研究也不例外。我们最近发现，对6周抗抑郁药物有反应的抑郁症患者，其顶叶/小脑区域的脑灌注增加，并且与健康对照受试者的脑灌注相似。我们现在展示从其中11名处于缓解期2年的患者收集的锝-99m六甲基丙烯胺肟单光子发射计算机断层扫描（99mTc-HMPAO SPECT）数据。使用统计参数映射分析图像。2年后，治疗后立即发现的灌注正常化得以维持，额叶灌注进一步增加，顶叶/小脑区域灌注减少。这些发现表明，顶叶/小脑区域的灌注增加可能参与治疗的急性反应，而额叶区域的增加可能与其巩固有关。
