Ogura A, Morinobu S, Kawakatsu S, Totsuka S, Komatani A
Department of Neuropsychiatry, Yamagata University School of Medicine, Japan.
Acta Psychiatr Scand. 1998 Jul;98(1):54-9. doi: 10.1111/j.1600-0447.1998.tb10042.x.
Relative regional cerebral blood flow was measured with single photon emission computed tomography (SPECT) using 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) in 16 patients with major depression while they were in the depressed state as well as in remission. All patients were closely matched with regard to medication status. In the depressed state, significant reductions in tracer uptake were found in the left superior frontal, bilateral parietal and right lateral temporal cortex. During remission, significant increases in uptake were found in the left superior frontal, right parietal and right lateral temporal cortex. There were no significant differences in tracer uptake between patients in remission and controls. These findings suggest that the regional decreases in tracer uptake observed in the depressed state might be a state-related abnormality.
在16例重度抑郁症患者处于抑郁状态及缓解期时，使用99m锝-六甲基丙烯胺肟（99mTc-HMPAO）通过单光子发射计算机断层扫描（SPECT）测量相对局部脑血流量。所有患者在用药情况方面均密切匹配。在抑郁状态下，发现左额上回、双侧顶叶和右侧颞叶外侧皮质的示踪剂摄取显著减少。在缓解期，左额上回、右侧顶叶和右侧颞叶外侧皮质的摄取显著增加。缓解期患者与对照组之间的示踪剂摄取无显著差异。这些发现表明，在抑郁状态下观察到的示踪剂摄取区域减少可能是一种与状态相关的异常。
