热暴露后院前药物浓度的改变。
Alteration in prehospital drug concentration after thermal exposure.
作者信息
Gammon Dustin L, Su Shujun, Jordan Janet, Patterson Robert, Finley Phillip J, Lowe Cindy, Huckfeldt Roger
机构信息
St. John's Emergency Medical Services, Springfield, MO 65804, USA.
出版信息
Am J Emerg Med. 2008 Jun;26(5):566-73. doi: 10.1016/j.ajem.2007.09.004.
OBJECTIVE
The aim of the study was to determine the remaining concentration of 23 commonly carried emergency medical services medications used in the United States after they have experienced thermal extremes that have been documented in the prehospital environment for a period of 1 month.
METHODS
Pharmaceuticals were thermally cycled (-6 degrees C and 54 degrees C) every 12 hours and then assayed by high-performance liquid chromatography.
RESULTS
Eight (35%) of 23 prehospital pharmaceuticals revealed ending concentrations of less than 90% with strong correlation to thermal exposure time. These included lidocaine, diltiazem, dopamine, nitroglycerin, ipratropium, succinylcholine, haloperidol, and naloxone.
CONCLUSION
A decrease in concentration was found to be statistically significant in 8 (35%) of 23 commonly carried emergency medical services pharmaceuticals. These results provide new information and perspective regarding stability of emergency drugs in the prehospital environment by evaluating a broad range of pharmaceuticals as well as by using thermal exposure points that have been documented in the United States.
目的
本研究的目的是确定美国常用的23种急诊医疗服务药物在经历极端温度后1个月内在院前环境中的剩余浓度，这些极端温度情况已有记录。
方法
药物每12小时进行一次热循环（-6摄氏度和54摄氏度），然后通过高效液相色谱法进行分析。
结果
23种院前药物中有8种（35%）的最终浓度低于90%，且与热暴露时间有很强的相关性。这些药物包括利多卡因、地尔硫卓、多巴胺、硝酸甘油、异丙托溴铵、琥珀酰胆碱、氟哌啶醇和纳洛酮。
结论
在23种常用的急诊医疗服务药物中，有8种（35%）的浓度下降具有统计学意义。这些结果通过评估多种药物以及使用美国已记录的热暴露点，提供了关于院前环境中急救药物稳定性的新信息和观点。
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