大型假体合金对感染率的影响。

The influence of the alloy of megaprostheses on infection rate.

作者信息

Gosheger Georg, Goetze Christian, Hardes Jendrik, Joosten Uwe, Winkelmann Winfried, von Eiff Christof

机构信息

Department of Orthopaedics, University Hospital of Münster, Münster, Germany.

出版信息

J Arthroplasty. 2008 Sep;23(6):916-20. doi: 10.1016/j.arth.2007.06.015. Epub 2008 Feb 13.

DOI:10.1016/j.arth.2007.06.015

PMID:18534530

Abstract

We retrospectively reviewed 197 patients who underwent reconstruction with a megaprosthesis of the lower extremity. A cobalt-chrome alloy system was used in 77 patients and a titanium alloy system in 120 patients. The overall infection rate was 20.8% (n = 41). Separated into the 2 prosthesis systems used, an infection rate of 31.2% was found in the patients with a cobalt-chrome-alloy prosthesis and 14.2% in the titanium alloy group of patients (P < .01). Early infection occurred in 5.1% (n = 10) and late infection in 15.7% (n = 31). Selecting 2 identical subgroups for further analysis, the cobalt-chrome alloy prostheses were associated with a significantly higher infection rate, with 5 infections of 26 megaprostheses vs 1 infection of 36 titanium megaprostheses (P < .05).

摘要

我们回顾性分析了197例行下肢大假体重建术的患者。其中77例患者使用钴铬合金系统，120例患者使用钛合金系统。总体感染率为20.8%（n = 41）。按所使用的两种假体系统分类，钴铬合金假体组患者的感染率为31.2%，钛合金假体组患者的感染率为14.2%（P < 0.01）。早期感染发生率为5.1%（n = 10），晚期感染发生率为15.7%（n = 31）。选取两个相同的亚组进行进一步分析，钴铬合金假体的感染率显著更高，26个大假体中有5例感染，而36个钛制大假体中有1例感染（P < 0.05）。