6周龄仔猪不存在对猪滑膜支原体感染的严格年龄相关抗性。

Absence of strictly age-related resistance to Mycoplasma hyosynoviae infection in 6-week-old pigs.

作者信息

Lauritsen Klara Tølbøll, Hagedorn-Olsen Tine, Friis Niels Filskov, Lind Peter, Jungersen Gregers

机构信息

Department of Veterinary Diagnostics and Research, National Veterinary Institute, The Technical University of Denmark, Copenhagen, Denmark.

出版信息

Vet Microbiol. 2008 Aug 25;130(3-4):385-90. doi: 10.1016/j.vetmic.2008.02.002. Epub 2008 Feb 15.

DOI:10.1016/j.vetmic.2008.02.002

PMID:18534787

Abstract

Mycoplasma hyosynoviae has never been reported to cause arthritis in pigs younger than 10 weeks of age. In order to investigate whether a strict age-related resistance exists, four 6-week-old pigs and four 13-week-old pigs, all immunologically naïve with respect to M. hyosynoviae, were inoculated intranasally with the agent and autopsied at day 11 or 13 after infection. One uninoculated pig per age group was included as a negative control. Just as the 13-week-old pigs, the 6-week-old piglets were susceptible to blood, joint and tonsillar infection with M. hyosynoviae and developed clinical arthritis following inoculation with the agent. Thus, we found no evidence of an age-related resistance to the infection.

摘要

猪鼻支原体从未被报道可引起10周龄以下仔猪的关节炎。为了研究是否存在严格的年龄相关抗性，将4头6周龄仔猪和4头13周龄仔猪（均对猪鼻支原体无免疫经验）经鼻接种该病原体，并在感染后第11天或第13天进行尸检。每个年龄组包括1头未接种的猪作为阴性对照。与13周龄仔猪一样，6周龄仔猪对猪鼻支原体的血液、关节和扁桃体感染敏感，并在接种病原体后出现临床关节炎。因此，我们没有发现与年龄相关的感染抗性证据。