Hübner W, Rurka I, Porpaczy P, Miko I
Department of Urology, Polyclinic Hospital, Vienna, Austria.
Urol Res. 1991;19(2):131-4. doi: 10.1007/BF00368191.
In 21 male dogs a 4- to 10-cm sections of the urethra was replaced by an autologous vein graft. After an observation period of 21-380 days (mean 118), the results of radiological, endoscopic, macroscopic and histological examination were evaluated for 19 animals; 2 of the animals died perioperatively. Micturition was normal in 18 of 19 animals until they were killed. One animal died on the 30th day due to a high-grade meatal stenosis with a subsequent episode of urine retention and ascending urinary infection. Gross examination of the graft in this animal, however, revealed a good result. The local surrounding tissue was found to be ideal in 11 animals, and 5 showed satisfactory results. Three times we observed a pronounced stenosis, so that in these cases results were judged to be unsatisfactory. Postmortem examinations showed the neo-urethra to be a tube made up of connective tissue completely lined by urothelium. In our opinion the results of these animal experiments could at least be equalled in clinical application.
在21只雄性犬中，用自体静脉移植物替换了4至10厘米长的尿道段。经过21至380天（平均118天）的观察期后，对19只动物的放射学、内镜、大体和组织学检查结果进行了评估；2只动物在围手术期死亡。19只动物中有18只排尿正常，直至被处死。1只动物在第30天因严重的尿道口狭窄继发尿潴留和上行性尿路感染而死亡。然而，对该动物移植物的大体检查显示结果良好。发现11只动物的局部周围组织理想，5只显示满意结果。我们三次观察到明显的狭窄，因此在这些病例中结果被判定为不满意。尸检显示新尿道是由完全被尿路上皮覆盖的结缔组织构成的管道。我们认为，这些动物实验的结果在临床应用中至少可以达到同等水平。
