Majane Olebogeng H I, Woodiwiss Angela J, Maseko Muzi J, Crowther Nigel J, Dessein Patrick H, Norton Gavin R
Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Am J Hypertens. 2008 Aug;21(8):936-42. doi: 10.1038/ajh.2008.203. Epub 2008 Jun 5.
We aimed to clarify whether age influences the independent relationship between adiposity and pulse-wave velocity (PWV).
We explored the effect of age on the independent relationships between indexes of central adiposity (waist circumference (WC) and waist-to-hip ratio (WHR)) and carotid-femoral PWV, central augmentation index (AIc), or pressure wave amplification assessed from applanation tonometry measurements obtained at the radial, carotid, and femoral arteries in 508 randomly selected subjects >16 years of age in a population sample of African ancestry with a high prevalence of excess adiposity ( approximately 63% overweight or obese).
In women a strong interaction between age and either WC or WHR was associated with logPWV independent of confounders and the individual terms (r = 0.68, P < 0.0001). This translated into a markedly greater increase in logPWV with increases in either WC or WHR in women older than the median age as compared to women younger (slopes of WC-logPWV relationships = 0.0031 +/- 0.0009 vs. -0.0007 +/- 0.0007, P < 0.002). In women older than the median age for the group, a one s.d. increase in WC (12.8 cm) translated into a 0.70 m/s increase in PWV as compared to a 0.14 m/s decrease in PWV for each one s.d. increase in WC (13.0 cm) in women younger than the median age (P < 0.001). No index of adiposity was independently associated with the log of AIc or aortic-brachial wave amplification.
In women of African ancestry, a greater independent effect of adiposity on PWV is noted in older as compared to younger women.
我们旨在阐明年龄是否会影响肥胖与脉搏波速度（PWV）之间的独立关系。
在一个肥胖率较高（约63%超重或肥胖）的非洲裔人群样本中，我们对508名年龄大于16岁的随机选取的受试者进行了研究，探讨年龄对中心性肥胖指标（腰围（WC）和腰臀比（WHR））与颈股PWV、中心增强指数（AIc）或根据在桡动脉、颈动脉和股动脉进行的压平眼压测量评估的压力波放大之间独立关系的影响。
在女性中，年龄与WC或WHR之间存在强烈的交互作用，与logPWV相关，且不受混杂因素和单个变量的影响（r = 0.68，P < 0.0001）。这意味着与年龄小于中位数的女性相比，年龄大于中位数的女性中，WC或WHR的增加会导致logPWV有明显更大的增加（WC与logPWV关系的斜率分别为0.0031±0.0009和 -0.0007±0.0007，P < 0.002）。在该组年龄大于中位数的女性中，WC每增加一个标准差（12.8 cm），PWV增加0.70 m/s，而年龄小于中位数的女性中，WC每增加一个标准差（13.0 cm），PWV降低0.14 m/s（P < 0.001）。没有肥胖指标与AIc的对数或主动脉 - 肱动脉波放大独立相关。
在非洲裔女性中，与年轻女性相比，肥胖对PWV的独立影响在老年女性中更为明显。
