Department of Internal Medicine, Division of Cardiology-Intensive Therapy Department of General, Gastroenterological and Endocrinological Surgery, University School of Medicine, 49 Przybyszewskiego, Poznan, Poland.
Br J Clin Pharmacol. 2012 Apr;73(4):546-52. doi: 10.1111/j.1365-2125.2011.04129.x.
Aortic-brachial pulse pressure amplification (PPA) is a measure of arterial elasticity and it is also an independent cardiovascular risk factor. The PPA is mainly determined by age, height, central and peripheral pressure waveforms characteristics, including measures of arterial stiffness and wave reflection.
In this study, however, we demonstrate that PPA is also significantly associated with indirect indices of body fatness. As the body fatness is treatable, our findings might be used as a reference for future studies on the effects of body fat reduction on PPA and the PPA-related cardiovascular risk. AIMS Arterial pressure transfer to the periphery is accompanied by pulse pressure amplification (PPA). Pulse pressure is influence by body fat. The purpose of the present study was to evaluate any possible inter-relation between body fatness and PPA in healthy subjects.
Haemodynamic and wave reflection indices were estimated by pulse wave analysis. Body fat was measured by bio-impedance.
A total of 367 healthy volunteers (136 men and 231 women) was studied. Pulse pressure amplification correlated significantly with percentage of body fat (r=-0.53, P < 0.0001), age (r=-0.62, P < 0.0001), height (r= 0.43, P < 0.0001), heart rate (r= 0.28, P < 0.0001) and mean blood pressure (r=-0.29, P < 0.0001). The association of PPA with body fat was also significant in a multiple linear regression model. Age was an independent predictor of PPA and analysis of study subjects subdivided into two groups, those <50 years and those >50 years showed that body fatness correlated inversely and significantly with PPA in individuals both younger and older than 50 years (r=-0.44, P < 0.0001, r=-0.37, P < 0.0001 respectively). Augmentation pressure was also associated significantly with percentage of body fat in both subgroups (r= 0.48, P < 0.0001 and r= 0.49, P < 0.0001 respectively).
This study performed on healthy subjects showed that pulse pressure amplification is related to body fatness over a wide age range. Percentage body fat is significantly associated with augmentation pressure, a component of central pulse pressure.
主动脉-肱动脉脉搏压放大（PPA）是动脉弹性的一种测量方法，也是心血管独立危险因素。PPA 主要由年龄、身高、中心和外周压力波特征决定，包括动脉僵硬和波反射的测量。
然而，在本研究中，我们证明 PPA 也与身体脂肪的间接指标显著相关。由于身体肥胖是可以治疗的，我们的研究结果可以作为未来关于减肥对 PPA 及与 PPA 相关心血管风险影响的研究参考。
动脉压力向周围传递伴随着脉搏压放大（PPA）。脉搏压受身体脂肪的影响。本研究的目的是评估健康受试者中体脂与 PPA 之间是否存在任何可能的相互关系。
通过脉搏波分析评估血流动力学和波反射指数。身体脂肪通过生物阻抗法测量。
共研究了 367 名健康志愿者（136 名男性和 231 名女性）。脉搏压放大与体脂百分比（r=-0.53，P<0.0001）、年龄（r=-0.62，P<0.0001）、身高（r=0.43，P<0.0001）、心率（r=0.28，P<0.0001）和平均血压（r=-0.29，P<0.0001）呈显著相关。PPA 与体脂的相关性在多元线性回归模型中也很显著。年龄是 PPA 的独立预测因子，对研究对象进行分组分析显示，<50 岁组和>50 岁组的个体中，体脂与 PPA 呈负相关且显著（r=-0.44，P<0.0001，r=-0.37，P<0.0001）。在这两个年龄组中，放大压力与体脂百分比也显著相关（r=0.48，P<0.0001，r=0.49，P<0.0001）。
本研究对健康受试者进行的研究表明，PPA 与广泛年龄范围内的体脂有关。体脂百分比与中心脉搏压的增强压力显著相关，增强压力是中央脉搏压的一个组成部分。
