The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
Eye (Lond). 2009 Apr;23(4):819-21. doi: 10.1038/eye.2008.146. Epub 2008 Jun 6.
One-fourth of the patients with exudative age-related macular degeneration (AMD) treated with an autologous retinal pigment epithelium (RPE)-choroid translocation had a hyperfluorescent optic disc with indocyanine green angiography (ICGA). This study aimed to identify whether indocyanine green (ICG)-assisted surgery was related to the hyperfluorescence of the optic disc with ICGA.
Retrospective observational case series of 31 AMD patients treated with an RPE-choroid translocation and who had ICGA after surgery. The ICGAs were assessed for hypo/iso/hyperfluorescence of the optic disc and fluorescence was related to the time interval between ICGA and the possible use of intravitreal ICG.
The optic disc was hyperfluorescent in six patients, isofluorescent in one, and hypofluorescent in 24 patients. All hyperfluorescent optic discs and 7 of the 24 hypofluorescent optic discs were preceded with ICG-assisted surgery with a time interval of 7+/-3 weeks and 43+/-12 weeks, respectively (P=0.001, Student t-test). The other 17 hypofluorescent discs were not preceded by ICG-assisted surgery and the one isofluorescent optic disc was observed 32 weeks after ICG-assisted surgery.
There was a statistically significant correlation between intravitreal ICG use during surgery and a hyperfluorescent optic disc with ICGA in our patient group.
接受自体视网膜色素上皮（RPE）-脉络膜转位治疗的渗出性年龄相关性黄斑变性（AMD）患者中有四分之一在吲哚菁绿血管造影（ICGA）中出现视神经盘高荧光。本研究旨在确定吲哚菁绿（ICG）辅助手术是否与 ICGA 中视神经盘高荧光有关。
回顾性观察性病例系列研究，纳入 31 名接受 RPE-脉络膜转位治疗且术后行 ICGA 的 AMD 患者。评估 ICGA 中视神经盘的低/等/高荧光，并将荧光与 ICGA 与可能使用玻璃体腔 ICG 之间的时间间隔相关联。
6 名患者的视神经盘呈高荧光，1 名患者呈等荧光，24 名患者呈低荧光。所有高荧光视神经盘和 24 个低荧光视神经盘中的 7 个和 7 个分别在前一次 ICGA 辅助手术中出现，时间间隔分别为 7+/-3 周和 43+/-12 周（P=0.001，Student t 检验）。其余 17 个低荧光视神经盘未行 ICG 辅助手术，1 个等荧光视神经盘在 ICGA 辅助手术后 32 周观察到。
在我们的患者群体中，手术中玻璃体腔注射 ICG 与 ICGA 中视神经盘高荧光之间存在统计学显著相关性。
