Maaijwee Kristel, Van Den Biesen Pieter R, Missotten Tom, Van Meurs Jan C
The Rotterdam Eye Hospital, Erasmus University, Rotterdam, The Netherlands.
Retina. 2008 Mar;28(3):498-503. doi: 10.1097/IAE.0b013e318159ec24.
To study graft perfusion using fluorescein angiography (FA) and indocyanine green angiography (ICG) after the translocation of an autologous retinal pigment epithelium (RPE)-choroid graft in patients with exudative age-related macular degeneration (AMD).
Retrospective observational case series of 31 patients with AMD who had FA and/or ICG performed after an RPE-choroid graft translocation. The FAs (n = 25) and ICGs (n = 23) were assessed by an independent masked reader for the presence of early fluorescence of the graft in FA, and for perfusion of the choroidal vessels of the graft and recipient bed in ICG.
Early fluorescence of the graft was present in 23 of the 25 FAs. Perfusion of the graft vasculature was observed in 12 of the 23 ICGs. The two grafts that lacked early fluorescence in FA also had no signs of choroidal perfusion of the graft and the recipient bed with ICG.
Revascularization of the RPE-choroid graft was observed in all but 2 of the 31 patients either by early fluorescence of the graft by FA or by identification of perfused choroidal graft vessels with ICG from 1 week up to 3 years after surgery. For assessment of revascularization of the graft evaluation of the early phase of the FA is recommended.
采用荧光素血管造影（FA）和吲哚菁绿血管造影（ICG）研究渗出性年龄相关性黄斑变性（AMD）患者自体视网膜色素上皮（RPE）-脉络膜移植片移位后的移植片灌注情况。
对31例AMD患者进行回顾性观察病例系列研究，这些患者在RPE-脉络膜移植片移位后接受了FA和/或ICG检查。由一名独立的盲法阅片者对25例FA和23例ICG进行评估，观察FA中移植片的早期荧光情况，以及ICG中移植片和受体床脉络膜血管的灌注情况。
25例FA中有23例出现移植片早期荧光。23例ICG中有12例观察到移植片血管系统灌注。FA中缺乏早期荧光的2例移植片在ICG中也未显示移植片和受体床脉络膜灌注的迹象。
在31例患者中，除2例患者外，其余患者在术后1周至3年期间，通过FA观察到移植片早期荧光或通过ICG识别出灌注的脉络膜移植血管，均观察到RPE-脉络膜移植片的血管再生。为评估移植片的血管再生情况，建议评估FA的早期阶段。
