Daughaday W H, Trivedi B
Washington University School of Medicine, Department of Medicine, Saint Louis, Missouri.
Acta Endocrinol (Copenh). 1991;124 Suppl 2:27-32.
The high affinity specific binding of 125I-hGH in human serum is attributable to the GH binding protein, which is derived from the extracellular domain of the receptor. Most measurements have been made by gel filtration methods and expressed with a normal human reference serum (RSGHB). The RSGHB is virtually unmeasurable in the cord sera of premature infants and is higher in cord serum of term infants. RSGHB rises progressively in childhood and reaches adult levels after age 20 years. GH deficiency or excess exerts little effect on RSGHB. RSGHB in GH resistance of the Laron-type is virtually undetectable and such measurements are confirmatory of the diagnosis. In African pygmies, the RSGHB fails to rise in late childhood and correlates with decreased IGF-I concentrations and reduced growth velocity at that time. Studies of abnormalities of the GH-BP in nutritional and other medical conditions are in their infancy, but will be greatly aided by simpler assay methods.
人血清中125I-人生长激素（hGH）的高亲和力特异性结合归因于生长激素结合蛋白，该蛋白来源于受体的细胞外结构域。大多数测量是通过凝胶过滤法进行的，并以正常人参考血清（RSGHB）表示。RSGHB在早产儿的脐血中几乎无法检测到，而在足月儿的脐血中则较高。RSGHB在儿童期逐渐升高，20岁后达到成人水平。生长激素缺乏或过量对RSGHB影响很小。拉伦型生长激素抵抗患者的RSGHB几乎无法检测到，此类测量结果可确诊该病。在非洲俾格米人中，RSGHB在儿童晚期未能升高，且与当时胰岛素样生长因子-I（IGF-I）浓度降低和生长速度减慢相关。关于营养及其他医学状况下生长激素结合蛋白（GH-BP）异常的研究尚处于起步阶段，但更简便的检测方法将极大地推动此类研究。
