Menne Jan, Haller Hermann
Department of Nephrology, Medical School Hannover, Hannover, Germany.
Drugs Today (Barc). 2008 Apr;44(4):261-70. doi: 10.1358/dot.2008.44.4.1164756.
The dihydropyridine calcium channel blocker lercanidipine and the ACE inhibitor enalapril are frequently used in the treatment of hypertensive patients. In April 2007, a fixed-dose combination of the two drugs was approved in Germany for the treatment of patients not responding to monotherapy. It is expected that the drug will soon be available in the other European Union markets. In this review the present literature is summarized. Two doses will be available with 10 mg lercanidipine each and 10 or 20 mg enalapril. The medication should be taken once daily, optimally =15 minutes before a meal and the consumption of grapefruit juice should be avoided. The fixed-dose combination of the two drugs has a stronger blood pressure-lowering effect than monotherapy with 20 mg enalapril or 10 mg lercanidipine. The combination is well tolerated and few patients stopped the treatment because of side effects. As expected, the most common side effects reported are cough, peripheral edema, flushing, dizziness and vertigo, occurring in 1-5% of patients. This new fixed-dose combination is a useful adjunct to the present treatment and should increase compliance and help reduce hypertension-related costs.
二氢吡啶类钙通道阻滞剂乐卡地平与血管紧张素转换酶抑制剂依那普利常用于治疗高血压患者。2007年4月，这两种药物的固定剂量复方制剂在德国获批，用于治疗对单一疗法无反应的患者。预计该药物很快将在欧盟其他市场上市。本综述总结了现有文献。该复方制剂有两种剂量，每种含10 mg乐卡地平与10或20 mg依那普利。该药应每日服用一次，最佳服药时间是饭前15分钟，且应避免饮用葡萄柚汁。两种药物的固定剂量复方制剂比单用20 mg依那普利或10 mg乐卡地平的降压效果更强。该复方制剂耐受性良好，很少有患者因副作用而停药。正如预期的那样，报告的最常见副作用是咳嗽、外周水肿、潮红、头晕和眩晕，发生率为1%至5%。这种新的固定剂量复方制剂是现有治疗的有用辅助药物，应能提高依从性并有助于降低与高血压相关的费用。
