Anthony Marietta, Lee Kwan Y, Bertram Carl T, Abarca Jacob, Rehfeld Rick A, Malone Daniel C, Freeman Marlene, Woosley Raymond L
The Critical Path Institute, Tucson, Arizona 85718, USA.
J Womens Health (Larchmt). 2008 Jun;17(5):735-43. doi: 10.1089/jwh.2007.0731.
Our objective was to compare sex and age differences in the medications dispensed in pharmacies from a large national drugstore chain.
Using a list for the 200 most commonly prescribed medicines, we assessed prescriptions dispensed by a large national chain drug store over 1 year (2002-2003). The analysis used U.S. census data adjusted for the population by sex and age and weighted by the number of pharmacies per state. Results are reported as an odds ratio (OR) of prescriptions dispensed to females and males.
Under age 18, 24 drug classes were dispensed more commonly to females (OR > 1) and 18 drug classes more commonly to males (OR < 1). In the 18-24 age group, 48 of 53 drug classes were dispensed more frequently to females. Across other adult groups, females were dispensed more medications than males for 156 of 180 medications. There was greater dispensing to females of antibiotics (OR = 1.74, 95% confidence interval [CI] 1.74-1.74), analgesics (OR = 1.70, 95% CI 1.70-1.70), antihistamines and sympathomimetics (OR = 1.46, 95% CI 1.45-1.46), benzodiazapines (OR = 2.08, 95% CI 2.07-2.08), antidepressants (OR = 2.40, 95% CI 2.39-2.40), diuretics (OR = 1.9328, 95% CI 1.93-1.94), and thyroid drugs (OR = 4.80, 95% CI 4.78-4.82). However, males had higher dispensing of antianginal drugs (OR = 0.84, 95% CI 0.83-0.85), anticoagulants (OR = 0.89, 95% CI 0.88-0.90), glycosides (OR = 0.80, 95% CI 0.79-0.81), and antihypertensives (OR = 0.91, 95% CI 0.91-0.91). More females were dispensed propoxyphene with acetaminophen (OR = 2.23, 95% CI 2.23-2.24), which has been associated with adverse outcomes (hospitalizations, emergency department visits, and deaths).
Females, especially during the reproductive years, are dispensed more medications than males.
我们的目的是比较一家大型全国连锁药店所售药品在性别和年龄上的差异。
我们使用200种最常用处方药清单，评估了一家大型全国连锁药店在1年（2002 - 2003年）内所配出的处方。分析使用了根据性别和年龄调整并按每个州药店数量加权的美国人口普查数据。结果以配发给女性和男性的处方的优势比（OR）报告。
18岁以下，有24类药物配发给女性更为常见（OR > 1），18类药物配发给男性更为常见（OR < 1）。在18 - 24岁年龄组中，53类药物中有48类配发给女性更为频繁。在其他成年组中，180种药物中有156种配发给女性的药物比男性多。女性配得更多的药物有抗生素（OR = 1.74，95%置信区间[CI] 1.74 - 1.74）、镇痛药（OR = 1.70，95% CI 1.70 - 1.70）、抗组胺药和拟交感神经药（OR = 1.46，95% CI 1.45 - 1.46）、苯二氮䓬类药物（OR = 2.08，95% CI 2.07 - 2.08）、抗抑郁药（OR = 2.40，95% CI 2.39 - 2.40）、利尿剂（OR = 1.9328，95% CI 1.93 - 1.94）和甲状腺药物（OR = 4.80，95% CI 4.78 - 4.82）。然而，男性配得更多的药物有抗心绞痛药（OR = 0.84，95% CI 0.83 - 0.85）、抗凝剂（OR = 0.89，95% CI 0.88 - 0.90）、强心苷类药物（OR = 0.80，95% CI 0.79 - 0.81）和抗高血压药（OR = 0.91，95% CI 0.91 - 0.91）。更多女性配得含对乙酰氨基酚的丙氧芬（OR = 2.23，95% CI 2.23 - 2.24），这与不良后果（住院、急诊就诊和死亡）相关。
女性，尤其是在生育年龄段，配得的药物比男性多。
