Mannix Lisa K
Headache Associates, West Chester, Ohio 45069, USA.
J Womens Health (Larchmt). 2008 Jun;17(5):879-91. doi: 10.1089/jwh.2007.0440.
Menstrual disorders affect millions of women in the United States and represent an important health burden. The most common menstrual disorders are dysmenorrhea and headache; these conditions are leading causes of work or school absenteeism and substantially impact quality of life. Headache associated with menses is often migraine and referred to as menstrual migraine. Although the pathogenesis of menstrual-related pain conditions is not fully understood, menstrual-related overproduction of prostaglandins is implicated in the pathophysiology of both menstrual migraine and dysmenorrhea. In clinical practice, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered the first-line therapeutic option for managing pain associated with dysmenorrhea. NSAIDs also play a role in the acute treatment and intermittent prophylaxis of migraine. Triptans, a class of highly selective serotonin receptor agonists, represent the gold standard for acute treatment of migraine. In addition, hormone therapy is effective in many cases for treating dysmenorrhea and may be beneficial in the management of menstrual migraine. Thus, overlapping treatment regimens may be advantageous in treating the coexisting menstrual-related pain conditions of dysmenorrhea and migraine.
月经失调影响着美国数百万女性，是一项重大的健康负担。最常见的月经失调是痛经和头痛；这些病症是导致工作或学校缺勤的主要原因，对生活质量有重大影响。与月经相关的头痛通常是偏头痛，被称为月经性偏头痛。尽管与月经相关的疼痛病症的发病机制尚未完全明确，但月经相关的前列腺素过度产生被认为与月经性偏头痛和痛经的病理生理有关。在临床实践中，非甾体抗炎药（NSAIDs）被视为治疗痛经相关疼痛的一线治疗选择。NSAIDs在偏头痛的急性治疗和间歇性预防中也发挥作用。曲坦类药物，一类高选择性5-羟色胺受体激动剂，是偏头痛急性治疗的金标准。此外，激素疗法在许多情况下对治疗痛经有效，可能对月经性偏头痛的管理有益。因此，重叠的治疗方案在治疗同时存在的痛经和偏头痛这两种与月经相关的疼痛病症时可能具有优势。
