Hudson Andrew R, Roach Steven L, Higuchi Robert I
Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA.
Curr Top Med Chem. 2008;8(9):750-65. doi: 10.2174/156802608784535048.
Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.
甾体糖皮质激素被广泛用于治疗多种炎症和自身免疫性疾病。尽管它们有效，但与长期糖皮质激素治疗相关的副作用，如骨质疏松和高血糖，会严重限制其长期使用。因此，需要开发新的全身性有效抗炎药物，使其与不良副作用脱钩。
