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血浆和血清中的循环核酸:在糖尿病和癌症诊断及预后中的作用

Circulating nucleic acids in plasma and serum: roles in diagnosis and prognosis in diabetes and cancer.

作者信息

Gahan Peter B

机构信息

Anatomy & Human Sciences, King's College London, London Bridge, London SE1 1UL, UK.

出版信息

Infect Disord Drug Targets. 2008 Jun;8(2):100-8. doi: 10.2174/187152608784746484.

DOI:10.2174/187152608784746484
PMID:18537705
Abstract

The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with metastases considered. The possible role(s) of the DNA/RNA in clinical diagnosis, in monitoring treatment and in prognosis are considered for diabetes and oncology.

摘要

本文描述了人类血浆和血清中循环的DNA和RNA的存在情况。讨论了血液中DNA/RNA的可能来源、它们进入其他细胞并在受体细胞中表达的能力,并考虑了其与转移的关系。还探讨了DNA/RNA在糖尿病和肿瘤学的临床诊断、治疗监测及预后方面可能发挥的作用。

相似文献

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Circulating nucleic acids in plasma and serum: roles in diagnosis and prognosis in diabetes and cancer.血浆和血清中的循环核酸:在糖尿病和癌症诊断及预后中的作用
Infect Disord Drug Targets. 2008 Jun;8(2):100-8. doi: 10.2174/187152608784746484.
2
Biology of circulating nucleic acids and possible roles in diagnosis and treatment in diabetes and cancer.循环核酸的生物学及其在糖尿病和癌症诊断与治疗中的可能作用。
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Circulating nucleic acids in plasma and serum: past, present and future.血浆和血清中的循环核酸:过去、现在与未来
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Circulating nucleic acids in plasma and serum: recent developments.血浆和血清中的循环核酸:最新进展
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[Circulating nucleic acids in blood of patients with stomach and colon neoplasms].
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Diagnostic potential of circulating nucleic acids for oncology.循环核酸在肿瘤学中的诊断潜力
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Circulating nucleic acids in plasma and serum: diagnosis and prognosis in cancer.循环核酸在血浆和血清中的检测:癌症的诊断和预后。
EPMA J. 2010 Sep;1(3):503-12. doi: 10.1007/s13167-010-0021-6. Epub 2010 Jun 9.
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Circulating nucleic acids as a tumor marker.循环核酸作为一种肿瘤标志物。
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Plasma nucleic acids in the diagnosis and management of malignant disease.血浆核酸在恶性疾病诊断与管理中的应用
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Cell-free DNA and RNA in plasma as new tools for molecular diagnostics.血浆中的游离DNA和RNA作为分子诊断的新工具。
Expert Rev Mol Diagn. 2003 Nov;3(6):785-97. doi: 10.1586/14737159.3.6.785.

引用本文的文献

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Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer.循环游离DNA作为转移性癌症患者分子监测工具的评估
Oncol Lett. 2020 Feb;19(2):1551-1558. doi: 10.3892/ol.2019.11192. Epub 2019 Dec 9.
2
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia.利用新生仔猪窒息模型检测尿液中的循环游离 DNA(cfDNA)。
PLoS One. 2019 Dec 31;14(12):e0227066. doi: 10.1371/journal.pone.0227066. eCollection 2019.
3
Circulating nucleic acids in plasma and serum: diagnosis and prognosis in cancer.
循环核酸在血浆和血清中的检测:癌症的诊断和预后。
EPMA J. 2010 Sep;1(3):503-12. doi: 10.1007/s13167-010-0021-6. Epub 2010 Jun 9.
4
Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures.糖尿病患者的癌症易感性:用于预测性诊断和靶向预防措施的风险因素。
EPMA J. 2010 Mar;1(1):130-7. doi: 10.1007/s13167-010-0015-4. Epub 2010 Mar 11.
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Time for new guidelines in advanced diabetes care: Paradigm change from delayed interventional approach to predictive, preventive & personalized medicine.先进糖尿病治疗的新指南制定时机已到:从延迟干预方法到预测性、预防性和个体化医学的范式转变。
EPMA J. 2010 Mar;1(1):3-12. doi: 10.1007/s13167-010-0014-5. Epub 2010 Mar 16.
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Opinion controversy to chromium picolinate therapy's safety and efficacy: ignoring 'anecdotes' of case reports or recognising individual risks and new guidelines urgency to introduce innovation by predictive diagnostics?对吡啶甲酸铬治疗的安全性和疗效的意见争议:是忽视病例报告的“传闻”,还是认识到个体风险和新指南通过预测性诊断引入创新的紧迫性?
EPMA J. 2012 Oct 7;3(1):11. doi: 10.1186/1878-5085-3-11.
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Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics.糖尿病护理中的吡啶甲酸铬疗法:个体治疗效果需要新的指南以及预测性诊断的引导。
Infect Disord Drug Targets. 2012 Oct;12(5):332-9. doi: 10.2174/187152612804142215.
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Chromium-picolinate therapy in diabetes care: molecular and subcellular profiling revealed a necessity for individual outcome prediction, personalised treatment algorithms and new guidelines.糖尿病护理中的吡啶甲酸铬疗法:分子和亚细胞分析揭示了个体预后预测、个性化治疗算法及新指南的必要性。
Infect Disord Drug Targets. 2011 Apr;11(2):188-95. doi: 10.2174/187152611795589717.
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Protocol for the quantitative assessment of DNA concentration and damage (fragmentation and nicks).DNA浓度及损伤(片段化和切口)定量评估方案
Nat Protoc. 2009;4(2):125-31. doi: 10.1038/nprot.2008.222.