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循环核酸在血浆和血清中的检测:癌症的诊断和预后。

Circulating nucleic acids in plasma and serum: diagnosis and prognosis in cancer.

机构信息

Anatomy & Human Sciences, King's College London, London Bridge, London, SE1 1UL UK.

出版信息

EPMA J. 2010 Sep;1(3):503-12. doi: 10.1007/s13167-010-0021-6. Epub 2010 Jun 9.

DOI:10.1007/s13167-010-0021-6
PMID:23199092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3405334/
Abstract

The presence of DNA and RNA circulating in human plasma and serum is described. The known sources of the DNA/RNA in blood, the ability of these nucleic acids to enter other cells and to express in the recipient cells are considered along with their relationship to metastases. The possible role(s) of the DNA/RNA in personalized clinical diagnosis, monitoring of treatment and prognosis in oncology are discussed.

摘要

本文描述了 DNA 和 RNA 存在于人类血浆和血清中的情况。考虑到血液中 DNA/RNA 的已知来源、这些核酸进入其他细胞并在受者细胞中表达的能力,以及它们与转移的关系,还讨论了这些核酸在个性化临床诊断、肿瘤治疗监测和预后中的可能作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5a/3405334/c2da03d86d67/13167_2010_21_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5a/3405334/c2da03d86d67/13167_2010_21_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b5a/3405334/c2da03d86d67/13167_2010_21_Fig1_HTML.jpg

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Plasma cell-free DNA in ovarian cancer: an independent prognostic biomarker.卵巢癌中的无细胞血浆 DNA:一种独立的预后生物标志物。
Cancer. 2010 Apr 15;116(8):1918-25. doi: 10.1002/cncr.24997.
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Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades.血清 DNA 可以定义不同级别脑胶质瘤的肿瘤特异性遗传和表观遗传标记物。
微卫星不稳定性评估对预测、预防和个性化医疗具有重要意义:现状与展望。
EPMA J. 2023 Jan 25;14(1):143-165. doi: 10.1007/s13167-023-00312-w. eCollection 2023 Mar.
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Changes in Endogenous and Exogenous Koala Retrovirus Subtype Expression over Time Reflect Koala Health Outcomes.时间推移中内源性和外源性考拉逆转录病毒亚型表达的变化反映了考拉的健康结果。
J Virol. 2019 Aug 28;93(18). doi: 10.1128/JVI.00849-19. Print 2019 Sep 15.
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Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer.瓜氨酸化组蛋白H3作为晚期癌症患者一种新的预后血液标志物。
PLoS One. 2018 Jan 11;13(1):e0191231. doi: 10.1371/journal.pone.0191231. eCollection 2018.
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