Pusiol Teresa, Parolari Anna Maria, Piscioli Francesco
Institute of Anatomic Pathology, "S,Maria del Carmine" Hospital Rovereto, Rovereto (TN), Italy.
Int Semin Surg Oncol. 2008 Jun 9;5:15. doi: 10.1186/1477-7800-5-15.
We report two cases of "uterine leiomyoma with tubules" as a new pathological entity. Since these are biphasic neoplasms (composed by epithelial and mesenchimal elements), the differential diagnosis is between mixed mullerian tumors and uterine tumors resembling ovarian sex cord tumors (UTROSCTs). In the differential diagnosis, the mixed mullerian tumors are easily excluded because of histological and immunohistochemical features. UTROSCTs are similar to the lesions we reported, and the differential diagnosis requires positivity for some immunohistochemical markers as inhibin, CD99, calretinin, Melan-A. Our conclusions are that to perform a diagnosis of UTROSCT at least two immunohistochemical marker have to be expressed; in the present case they didn't, so we call the lesion "leiomyoma with tubules".
我们报告了两例“伴有小管的子宫平滑肌瘤”，这是一种新的病理实体。由于这些是双相性肿瘤（由上皮和间充质成分组成），鉴别诊断包括混合性苗勒管肿瘤和类似卵巢性索肿瘤的子宫肿瘤（UTROSCT）。在鉴别诊断中，混合性苗勒管肿瘤因其组织学和免疫组化特征很容易被排除。UTROSCT与我们报告的病变相似，鉴别诊断需要一些免疫组化标志物呈阳性，如抑制素、CD99、钙视网膜蛋白、黑色素A。我们的结论是，要诊断UTROSCT至少必须有两种免疫组化标志物表达；在本病例中它们并未表达，所以我们将该病变称为“伴有小管的平滑肌瘤”。
