Ueki M
Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
Am J Obstet Gynecol. 1991 Jul;165(1):201-9. doi: 10.1016/0002-9378(91)90252-m.
Histologic study of endometriosis and investigation of lymphatic drainage in and out of the uterus were conducted to obtain more information on the histogenesis of endometriosis. Endometriosis is a disease originating from the normal endometrium, specifically from its basal layer. Internal endometriosis (adenomyosis) is caused mainly by direct invasion of the endometrium into the spaces located in the connective tissue of the muscle layer. Serous and ovarian types of endometriosis are frequently found together with adenomyosis. Endometrial fragments in vessels are detected in 4.5% of cases of endometriosis. Observation of serial sections proved that serous endometriosis is caused mainly by continuous or semicontinuous invasion of the tunica muscularis spaces primarily from adenomyosis lesions and partly from the endometrium. Confirmation of lymph flow into the ovary from the uterine body strongly suggests that ovarian endometriosis arises as a consequence of vascular (lymphatic) transport of endometrial fragments from adenomyosis lesions, serous endometriosis lesions, or the endometrium.
为了获取更多关于子宫内膜异位症组织发生的信息，对子宫内膜异位症进行了组织学研究，并对子宫内外的淋巴引流进行了调查。子宫内膜异位症是一种起源于正常子宫内膜，特别是其基底层的疾病。内在性子宫内膜异位症（子宫腺肌病）主要是由子宫内膜直接侵入肌层结缔组织中的间隙引起的。浆液性和卵巢型子宫内膜异位症常与子宫腺肌病同时出现。在4.5%的子宫内膜异位症病例中可检测到血管内的子宫内膜碎片。连续切片观察证明，浆液性子宫内膜异位症主要是由肌层间隙的连续或半连续侵入引起的，主要来自子宫腺肌病病变，部分来自子宫内膜。证实淋巴从子宫体流入卵巢，强烈提示卵巢子宫内膜异位症是子宫腺肌病病变、浆液性子宫内膜异位症病变或子宫内膜的子宫内膜碎片经血管（淋巴）运输的结果。
