Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss.
作者信息
Hopmeier Pierre, Puehringer Helene, van Trotsenburg Mick, Atamaniuk Johanna, Oberkanins Christian, Dossenbach-Glaninger Astrid
机构信息
Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
出版信息
Clin Biochem. 2008 Aug;41(12):1022-4. doi: 10.1016/j.clinbiochem.2008.05.004. Epub 2008 May 27.
OBJECTIVES
We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden.
DESIGN AND METHODS
We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls.
RESULTS
In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0.
CONCLUSIONS
The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.
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