Henderson D J, Bennett P R, Rodeck C H, Gau G S, Blunt S, Moore G E
Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Postgraduate Medical School, London, United Kingdom.
Am J Obstet Gynecol. 1991 Jul;165(1):98-102. doi: 10.1016/0002-9378(91)90233-h.
In a series of 14 anembryonic pregnancies, deoxyribonucleic acid from trophoblast was examined with locus-specific minisatellite probes. It was found in each case that trophoblast from anembryonic pregnancy has both a maternal and a paternal contribution to its genome. This means that although anembryonic pregnancy shares characteristics with complete hydatidiform mole and androgenetic development in the mouse in that there is no embryo, it does not arise by the same genetic process. Of three anembryonic pregnancies that were successfully karyotyped, two had normal female 46,XX chromosome constitutions and one had an abnormal 47,XX + 16 complement. The sex of the trophoblast in each anembryonic pregnancy was determined with a deoxyribonucleic acid probe with Y-specific bands. A male-to-female ratio of 6:8 was found, which is not significantly different from normal.
在一系列14例无胚胎妊娠中，使用位点特异性小卫星探针检测了来自滋养层的脱氧核糖核酸。结果发现在每例无胚胎妊娠中，滋养层的基因组都有母方和父方的贡献。这意味着，尽管无胚胎妊娠与完全性葡萄胎以及小鼠的孤雄发育有共同特征，即没有胚胎，但它并非由相同的遗传过程产生。在成功进行核型分析的3例无胚胎妊娠中，2例具有正常的女性46,XX染色体组成，1例具有异常的47,XX + 16染色体组型。使用具有Y特异性条带的脱氧核糖核酸探针确定了每例无胚胎妊娠中滋养层的性别。发现男女比例为6:8，与正常情况无显著差异。
