Kirnö K, Kunimoto M, Lundin S, Elam M, Wallin B G
Department of Anesthesia, Sahlgren's Hospital, Göteborg, Sweden.
Anesth Analg. 1991 Aug;73(2):138-42.
To study the relationship between skin sympathetic nerve activity and changes in skin resistance (galvanic skin response--GSR), efferent sympathetic and sensory nerves to the hand were blocked by an axillary nerve blockade in 15 healthy subjects. Subsequently, intraneural electrical stimuli in the median nerve distal to the axillary nerve block were used to evoke changes in skin resistance and in water vapor partial pressure in the sensory and sympathetically denervated hand. With increasing frequency of stimulation, skin resistance decreased and water vapor partial pressure increased until stimuli exceeded 10 Hz. When an additional burst of impulses was added to the background stimulation, GSR amplitude varied in a nonlinear fashion with the background frequency. Stimulation-induced GSR was completely abolished in a dose-dependent manner by systemically (intravenously) administered atropine. The results indicate that GSR depends on the preceding level of nerve traffic in the sympathetic sudomotor nerve fibers. Consequently, skin resistance recordings cannot be used to quantify sympathetic nerve traffic and thus do not express the completeness of sympathetic blockade in regional anesthesia.
为研究皮肤交感神经活动与皮肤电阻变化（皮肤电反应——GSR）之间的关系，对15名健康受试者进行腋神经阻滞，以阻断手部的传出交感神经和感觉神经。随后，在腋神经阻滞远端的正中神经内进行神经内电刺激，以诱发感觉和交感神经去神经支配的手部皮肤电阻和水蒸气分压的变化。随着刺激频率增加，皮肤电阻降低，水蒸气分压升高，直至刺激超过10Hz。当在背景刺激中额外添加一串冲动时，GSR幅度随背景频率呈非线性变化。全身（静脉）给予阿托品后，刺激诱发的GSR以剂量依赖方式完全消失。结果表明，GSR取决于交感汗腺运动神经纤维中先前的神经活动水平。因此，皮肤电阻记录不能用于量化交感神经活动，因而不能反映区域麻醉中交感神经阻滞的完整性。
