Moshchev D A, Sazonova O B, Ogurtsova A A, Lubnin A Iu
Anesteziol Reanimatol. 2008 Mar-Apr(2):11-6.
The present study was undertaken to evaluate the effects of sevoflurane on spontaneous brain bioelectrical activity in neurosurgical patients. Forty patients treated at the Research Institute of Neurosurgery underwent a neurophysiological examination. No epileptic syndrome was revealed in the clinical picture in 10 patients (a control group), the remaining 30 patients had a history of varying epileptic seizures of different degrees and frequency. Sevoflurane causes a relative acceleration of epileptiform activity synchronization, as evidenced by EEG, which is not a contraindication to the use of this drug in patients with cerebral organic lesion of various genesis with a history of epileptic syndrome and fails to induce clinically significant EEG epileptiform manifestations in patients without epilepsy. In patients with cerebrovascular abnormalities (arteriovenous malformation, cavernous angiomas) who have a history of paroxysmal conditions, inhalational sevoflurane anesthesia can be performed in combination with anticonvulsants (benzodiazepines) during an operation.
本研究旨在评估七氟醚对神经外科手术患者自发性脑生物电活动的影响。在神经外科研究所接受治疗的40例患者接受了神经生理学检查。10例患者（对照组）的临床表现未显示癫痫综合征，其余30例患者有不同程度和频率的癫痫发作史。脑电图显示，七氟醚可使癫痫样活动同步相对加速，这对于有癫痫综合征病史的各种病因的脑器质性病变患者并非使用该药物的禁忌证，且在无癫痫患者中不会诱发具有临床意义的脑电图癫痫样表现。对于有发作性疾病病史的脑血管异常（动静脉畸形、海绵状血管瘤）患者，手术期间吸入七氟醚麻醉可与抗惊厥药（苯二氮䓬类）联合使用。
