Rylova A V, Sazonova O B, Lubnin A Iu, Masherov E L
Anesteziol Reanimatol. 2010 Mar-Apr(2):31-3.
Xenon is a promising anesthetic agent in neurosurgery. However, there is now little evidence on the effect of xenon at anesthetic concentrations on brain electrical activity, which limits its use in neurosurgical patients. Changes in brain bioelectrical activity were studied in patients with skull base tumors before surgery (conscious ones) and at different stages of xenon anesthesia (after denitrogenization, at 50% xenon concentration in the circuit, at 65% xenon concentration in the circuit, during steady-state xenon anesthesia, and after hyperventilation). EEG during xenon anesthesia was similar to that during propofol anesthesia; a circuit xenon concentration (50 or 65%) and a ventilation mode had no considerable impact on EEG. Xenon did not induce paroxysmal activity. The findings suggest that the use of xenon anesthesia in neurosurgical patients is safe in terms of its impact on brain bioelectrical activity.
氙气是神经外科手术中一种很有前景的麻醉剂。然而，目前关于麻醉浓度的氙气对脑电活动影响的证据很少，这限制了其在神经外科手术患者中的应用。研究了颅底肿瘤患者在手术前（清醒状态）以及氙气麻醉不同阶段（去氮后、回路中氙气浓度为50%时、回路中氙气浓度为65%时、氙气麻醉稳态期间以及过度通气后）的脑生物电活动变化。氙气麻醉期间的脑电图与丙泊酚麻醉期间相似；回路中氙气浓度（50%或65%）和通气模式对脑电图没有显著影响。氙气不会诱发阵发性活动。研究结果表明，就氙气麻醉对脑生物电活动的影响而言，在神经外科手术患者中使用氙气麻醉是安全的。
