Tranquilli W J, Graning L M, Thurmon J C, Benson G J, Moum S G, Lentz E L
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1991 May;52(5):662-4.
The thiamylal sparing effect of midazolam was studied in 30 healthy Beagle and mixed-breed dogs. Using a replicated Latin square design, all dogs were given placebo (saline solution) and 0.025, 0.05, 0.1, and 0.2 mg of midazolam/kg of body weight prior to IV administration of thiamylal sodium. The 0.1 and 0.2 mg/kg dosages significantly decreased the amount of thiamylal required to obtund swallowing reflex and easily achieve endotracheal intubation. Midazolam at 0.1 and 0.2 mg/kg reduced thiamylal requirement by 16.4% and 18.9%, respectively, whereas the 0.05 mg/kg dosage decreased thiamylal requirement by only 6.8%. The 0.2 mg/kg dosage did not further decrease thiamylal requirement beyond that achieved with the 0.1 mg/kg dosage of midazolam. This study demonstrates that the preanesthetic IV administration of midazolam reduces the thiamylal dose necessary to accomplish intubation. The optimal preanesthetic dosage (lowest dosage with significant effect) was 0.1 mg/kg.
在30只健康的比格犬和混种犬中研究了咪达唑仑对硫喷妥钠的节省效应。采用重复拉丁方设计，在静脉注射硫喷妥钠之前，给所有犬只给予安慰剂（生理盐水溶液）以及0.025、0.05、0.1和0.2毫克/千克体重的咪达唑仑。0.1和0.2毫克/千克的剂量显著减少了抑制吞咽反射并轻松实现气管插管所需的硫喷妥钠量。0.1和0.2毫克/千克的咪达唑仑分别使硫喷妥钠需求量降低了16.4%和18.9%，而0.05毫克/千克的剂量仅使硫喷妥钠需求量降低了6.8%。0.2毫克/千克的剂量并未比0.1毫克/千克的咪达唑仑剂量进一步降低硫喷妥钠需求量。这项研究表明，麻醉前静脉注射咪达唑仑可减少完成插管所需的硫喷妥钠剂量。最佳麻醉前剂量（具有显著效果的最低剂量）为0.1毫克/千克。
