Greene S A, Benson G J, Hartsfield S M
Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman.
Vet Surg. 1993 Jan-Feb;22(1):69-72. doi: 10.1111/j.1532-950x.1993.tb00373.x.
One hundred eighteen dogs were studied at three veterinary teaching hospitals after the administration of midazolam (0.1 mg/kg, intravenously [IV]) or a placebo. Midazolam and placebo treatments were randomized and blinded to the investigators. The dose of thiamylal required for tracheal intubation 3 to 5 minutes after midazolam or placebo was calculated. The dose of thiamylal at the three hospitals was 10.6, 9.8, and 10.1 mg/kg i.v. after midazolam, and 12.1, 11.2, and 11.6 mg/kg i.v. after placebo. Pooled data from the three hospitals yielded a significant (p < .001) decrease in mean IV thiamylal dose after midazolam (10.2 mg/kg) compared with placebo (11.6 mg/kg). Overall, there was a 12% decrease in the dose of thiamylal required for tracheal intubation after midazolam compared to that after the placebo. The thiamylal dose was significantly (p < .001) decreased after midazolam compared with placebo for dogs weighing more than 15 kg but not for dogs weighing less than 15 kg.
在三家兽医教学医院，对118只犬在静脉注射咪达唑仑（0.1mg/kg）或安慰剂后进行了研究。咪达唑仑和安慰剂治疗随机分配，研究人员对此不知情。计算了在注射咪达唑仑或安慰剂后3至5分钟进行气管插管所需的硫喷妥钠剂量。在三家医院，注射咪达唑仑后硫喷妥钠的静脉注射剂量分别为10.6、9.8和10.1mg/kg，注射安慰剂后分别为12.1、11.2和11.6mg/kg。来自三家医院的汇总数据显示，与安慰剂组（11.6mg/kg）相比，注射咪达唑仑后硫喷妥钠的平均静脉注射剂量显著降低（p <.001）（10.2mg/kg）。总体而言，与安慰剂相比，注射咪达唑仑后气管插管所需的硫喷妥钠剂量降低了12%。与安慰剂相比，体重超过15kg的犬在注射咪达唑仑后硫喷妥钠剂量显著降低（p <.001），但体重低于15kg的犬则不然。
