Ogita Shin, Llaguna Omar H, Feldman Sheldon M, Blum Ronald
Department of Medicine, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York, USA.
Breast J. 2008 Jul-Aug;14(4):382-4. doi: 10.1111/j.1524-4741.2008.00604.x.
Paraneoplastic cerebellar degeneration (PCD) is a rare paraneoplastic syndrome, occurring in <1% of breast cancers. We describe a 32-year-old female presenting with ataxia subsequently diagnosed with poorly differentiated breast cancer. She was serum anti-Yo antibody positive, with estrogen/progesterone receptor negative and HER2/neu receptor positive breast cancer. Neurological symptoms progressed despite modified radical mastectomy, supraclavicular lymphadenectomy, intravenous immunoglobulin, corticosteroids, transtuzumab, and combination chemotherapy. We performed a literature search, which found a possible association between anti-Yo positive PCD and HER2/neu-expressing breast cancer.
副肿瘤性小脑变性（PCD）是一种罕见的副肿瘤综合征，在不到1%的乳腺癌患者中出现。我们描述了一名32岁女性，出现共济失调，随后被诊断为低分化乳腺癌。她血清抗Yo抗体呈阳性，患有雌激素/孕激素受体阴性且HER2/neu受体阳性的乳腺癌。尽管进行了改良根治性乳房切除术、锁骨上淋巴结清扫术、静脉注射免疫球蛋白、使用皮质类固醇、曲妥珠单抗及联合化疗，其神经症状仍有进展。我们进行了文献检索，发现抗Yo阳性PCD与HER2/neu表达型乳腺癌之间可能存在关联。
